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Anti-inflammatory Pathway
- Molecular classification
- Signaling Pathway, Neuro-immune Circuit, Cytokine Network
01
Overview
The anti-inflammatory pathway is a complex network of molecular and cellular mechanisms that actively suppress or resolve inflammation, maintaining tissue homeostasis and preventing excessive immune responses. It involves neuro-immune circuits like the cholinergic anti-inflammatory pathway (CAP), neuroendocrine regulation via the HPA axis and SNS, and cytokine networks mediated by anti-inflammatory molecules such as IL-10 and TGFβ. Dysregulation contributes to chronic inflammatory diseases.
- Other names
- Inflammation Resolution PathwayResolution of InflammationNeuroimmune Regulation of Inflammation
02
Mechanism of action
Various, depending on the targeted component. NSAIDs inhibit COX enzymes, glucocorticoids suppress gene transcription, JAK inhibitors block cytokine signaling.
03
Biological functions
Immune response regulationHomeostasis maintenanceInflammation resolutionNeuroimmune modulationTissue repair
04
Disease associations
InflammationNeurodegenerationCancerDiabetesCardiovascular diseaseInflammatory bowel disease
05
Safety considerations
ImmunosuppressionIncreased risk of infectionHPA axis suppressionGastrointestinal side effects (NSAIDs)Cardiovascular risks (NSAIDs)
06
Interacting drugs
NSAIDs
4 more in the full profile.
07
Biomarkers
Cytokine levels (IL-10, TGFβ, TNF-α)Inflammatory markers (CRP, ESR)Vagal tone (HRV)Glucocorticoid levels
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