Anti-inflammatory Protein Pathways (None)

Anti-inflammatory protein pathways are molecular signaling routes and mechanisms by which specific proteins and peptides suppress or resolve inflammation in tissues. These pathways are crucial for maintaining immune homeostasis, preventing excessive tissue damage, and resolving inflammatory responses after infection or injury. Key pathways involved include NF-κB, MAPK, cAMP signaling, and Keap1/Nrf2/ARE. They function by downregulating proinflammatory cytokine production, upregulating anti‑inflammatory mediators, limiting leukocyte recruitment/migration, and promoting the resolution phase of inflammation. Dysregulation of these pathways contributes to various inflammatory diseases, making them therapeutic targets for biologics and small molecules.

Modulation of NF-κB, MAPK, cAMP, and Nrf2/ARE pathways to suppress inflammation and promote tissue repair.