Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Anti-Müllerian Hormone Receptor Type 2 (None)
- Target
- None
- Molecular classification
- Receptor, Transforming Growth Factor Beta (TGF‑β) Type II Receptors, Transmembrane serine/threonine kinase receptor
01
Overview
Anti-Müllerian hormone receptor type 2 (AMHR2), also known as Müllerian Inhibiting Substance Type II Receptor, is a transmembrane serine/threonine kinase receptor that specifically binds anti-Müllerian hormone (AMH). It plays a critical role in sexual differentiation and reproductive system development. AMHR2 mediates signaling by binding anti-Müllerian hormone (AMH), which triggers regression of the Müllerian ducts during male embryonic development and regulates folliculogenesis and ovarian function in females. Measurement of circulating AMH serves as a biomarker for ovarian reserve/fertility assessment and diagnosis/monitoring of reproductive disorders.
- Other names
- Müllerian Inhibiting Substance Type II ReceptorMISRII
02
Mechanism of action
Binding of anti-Müllerian hormone (AMH) to AMHR2 triggers downstream SMAD signaling.
03
Biological functions
Signal transductionMüllerian duct regressionRegulation of gonadal functionSexual differentiationFolliculogenesis
04
Disease associations
Persistent Müllerian Duct SyndromePolycystic Ovary SyndromePremature Ovarian FailureSex reversal phenotypesInfertility
05
Safety considerations
Mutations affecting either ligand or receptor can cause disorders like persistent Müllerian duct syndrome.
06
Biomarkers
Circulating AMH levels as a biomarker for ovarian reserve/fertility assessment
Beyond the preview
Go deeper on Anti-Müllerian Hormone Receptor Type 2 (None).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Anti-Müllerian Hormone Receptor Type 2 (None).