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Anti-Müllerian Hormone Receptor Type II (None)
- Target
- None
- Molecular classification
- Receptor, TGF-β superfamily – Type II Serine/Threonine Kinase Receptors, Type I membrane protein
01
Overview
Anti-Müllerian hormone receptor type II (AMHR2) is a transmembrane serine/threonine kinase receptor that specifically binds anti-Müllerian hormone (AMH). AMHR2 is essential for mediating the biological effects of AMH, particularly in reproductive development and function. Upon binding AMH, AMHR2 activates downstream signaling pathways involving ALK-type I kinases and SMAD proteins, ultimately regulating gene expression. Loss-of-function mutations in AMHR2 are associated with persistent Müllerian duct syndrome.
- Other names
- Müllerian Inhibiting Substance Type II Receptor
02
Mechanism of action
Serine/threonine kinase receptor activation; SMAD pathway activation
03
Biological functions
Mediates regression of Müllerian ductsRegulates gonadal functionsSignal transduction
04
Disease associations
Persistent Müllerian duct syndromeSex reversal
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