Antibacterial effect on cutaneous microflora

This entry does not describe a discrete molecular or proteinaceous target; instead, it refers to the therapeutic or pharmacologic effect of antibacterial agents (including antibiotics, non-antibiotic topical agents, and probiotics) on the skin’s microbiota (skin flora)[1][2][3][4][6]. These agents are used to alter the balance of commensal and pathogenic microbes in the skin, often to restore health in the context of cutaneous infections, inflammation (e.g., atopic dermatitis, acne), or impaired wound healing. Strategies include direct killing or inhibition of bacterial growth (e.g., antibiotics), disruption of biofilms, competitive exclusion by beneficial microbes (probiotics), and stimulation of the host’s own antimicrobial peptides[1][2][3][4][6]. Although regulating cutaneous microflora is a promising therapeutic strategy, it carries risks including resistance development, microbiome disruption (dysbiosis), and potential adverse effects from probiotics[4][2].

Other names

Antibacterial effect on skin microbiotaAntibacterial effect on skin floraAntibacterial modulation of cutaneous microflora

Direct antimicrobial activity; Modulation of microbial colonization; Biofilm inhibition; Induction of antimicrobial peptides; Immunomodulation; Barrier restoration