Target intelligence / Profile preview

Immunoglobulin (Ig)

Target
Ig
Molecular classification
Glycoprotein, Antibody
01

Overview

Immunoglobulins, also known as antibodies, are glycoprotein molecules that serve as critical components of the immune system. These complex proteins are produced by plasma cells and play an essential role in recognizing and binding to specific antigens, such as bacteria, viruses, and fungi, to aid in their destruction. They exist in five main classes (IgG, IgM, IgA, IgD, and IgE), each with distinct functions in the humoral immune response. Immunoglobulins can be therapeutic targets as well as therapeutic agents (e.g. monoclonal antibodies).

Other names
AntibodyIgGIgMIgAIgDIgE
02

Mechanism of action

Monoclonal antibodies: Target specific antigens or receptors to neutralize their activity or induce cell death. IVIG: Provides passive immunity and modulates the immune system through various mechanisms, including Fc receptor interactions and complement modulation.

03

Biological functions

Antigen recognitionAntigen neutralizationOpsonizationComplement activationB cell receptor signalingCytokine secretion
04

Disease associations

InfectionAutoimmunityAllergyCancerImmunodeficiency
05

Safety considerations

Infusion reactionsAnaphylaxisSerum sicknessIncreased risk of infectionHypogammaglobulinemia
06

Interacting drugs

Monoclonal antibodies (e.g., adalimumab, infliximab, rituximab)

1 more in the full profile.

07

Biomarkers

IgG levelsIgM levelsIgA levelsIgE levelsSpecific antibody titers against pathogensB cell counts

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