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Target intelligence / Profile preview
Antibody-dependent Cell Cytotoxicity Mediator (via Fc) (ADCC)
- Target
- ADCC
- Molecular classification
- Immune response mediator, Fc receptor signaling pathway
01
Overview
Antibody-dependent cell-mediated cytotoxicity (ADCC) is an immune defense mechanism in which effector cells of the immune system actively lyse a target cell that has been bound by specific antibodies. This process is mediated through the interaction between the Fc region of antibodies and Fc receptors on effector cells.
- Other names
- Antibody-dependent cellular cytotoxicityAntibody-dependent cell-mediated cytotoxicity
02
Mechanism of action
Antibodies bind target cells, Fc region engages Fc receptors on effector cells, activating cytotoxic response.
03
Biological functions
Immune responseCell lysisApoptosis inductionTargeted cell killing
04
Disease associations
InfectionCancerAutoimmunity (potential)
05
Safety considerations
Cytokine release syndromeOff-target cytotoxicity
06
Interacting drugs
Therapeutic monoclonal antibodies (e.g., Rituximab, Trastuzumab)
07
Biomarkers
FCGR3A polymorphisms (e.g., V158F)Antibody glycosylation patterns (fucosylation)Antigen density on target cells
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