Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Antibody-dependent Cellular Cytotoxicity (ADCC)
- Target
- ADCC
- Molecular classification
- Immune process
01
Overview
Antibody-dependent cellular cytotoxicity (ADCC) is an immune mechanism where effector cells, such as NK cells, lyse target cells coated with antibodies. The process involves antibodies binding to antigens on target cells, followed by the Fc region of the antibodies interacting with Fc receptors (e.g., CD16/FcγRIIIa) on effector cells, leading to target cell lysis.
- Other names
- Antibody-dependent cell-mediated cytotoxicity
02
Mechanism of action
Monoclonal antibodies bind to target cells and recruit effector immune cells (e.g., NK cells) to induce cell lysis through the release of cytotoxic granules or expression of death-inducing molecules.
03
Biological functions
Lysis of antibody-coated target cellsKilling of infected cellsKilling of tumor cells
04
Disease associations
Viral infectionsCancer
05
Safety considerations
Off-target effects of antibodiesCytokine release syndrome
06
Interacting drugs
Therapeutic monoclonal antibodies
07
Biomarkers
FcγRIIIa polymorphismsAntibody glycosylation profileAntibody subclass
Beyond the preview
Go deeper on Antibody-dependent Cellular Cytotoxicity (ADCC).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Antibody-dependent Cellular Cytotoxicity (ADCC).