Antibody to Streptococcus pneumoniae serotype 6B capsular polysaccharide

Serotype 6B-specific antibodies are circulating immunoglobulins, primarily of the IgG class, directed against the capsular polysaccharide of Streptococcus pneumoniae serotype 6B. These antibodies are generated naturally after invasive disease or in response to pneumococcal vaccination (such as with PPSV23 or PCV7/13 vaccines, which contain the 6B antigen)[5][1]. Their presence and titer are used as biomarkers to assess immune protection against serotype 6B infection and as diagnostic markers for humoral immune competence in evaluating specific antibody deficiency[2][3][6][8]. Protective thresholds of serotype 6B-specific IgG (e.g., >0.35 to 1.3 µg/mL) are used as surrogate endpoints for vaccine efficacy and immune competence[3][8]. These antibodies are not drug targets but markers for assessing the effectiveness of vaccination and humoral immunity in clinical immunology[2][6][8].

Other names

Serotype 6B-specific IgGPneumococcal serotype 6B polysaccharide antibodyAnti-6B antibody