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Antigen 85 Complex B (Ag85B)
- Target
- Ag85B
- Molecular classification
- Enzyme, Mycolyltransferase, Fibronectin-binding protein
01
Overview
Antigen 85B (Ag85B) is an abundant secreted enzyme crucial for Mycobacterium tuberculosis cell wall construction via mycolic acid transfer reactions; it binds host fibronectin aiding infection establishment; it provokes robust immune responses making it valuable both diagnostically and as a vaccine/drug target against TB.
02
Mechanism of action
Inhibition of mycolyltransferase activity disrupts cell wall synthesis
03
Biological functions
Cell wall biogenesisMycolic acid transferCell adhesionImmune response
04
Disease associations
InfectionTuberculosis
05
Biomarkers
T-cell proliferationIFN-gamma secretion
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