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Target intelligence / Profile preview
Mycobacterium tuberculosis Antigen Ag85A (Ag85A)
- Target
- Ag85A
- Molecular classification
- Enzyme, Mycolyltransferase, Diacylglycerol acyltransferase, Secretory protein
01
Overview
Ag85A is a major secretory protein and mycolyltransferase enzyme produced by *Mycobacterium tuberculosis*. It is part of the antigen 85 complex and plays critical roles in cell wall biosynthesis, host-pathogen interactions, and bacterial persistence. Ag85A elicits strong T-cell mediated immune responses, making it an attractive candidate for TB vaccine development.
- Other names
- Antigen 85ADiacylglycerol acyltransferase/mycolyltransferase FbpAFbpA
02
Mechanism of action
N/A
03
Biological functions
Cell wall biosynthesisMycolic acid transferTrehalose dimycolate (TDM) synthesisTriacylglycerol (TAG) synthesisFibronectin bindingImmune response elicitation
04
Disease associations
Tuberculosis (TB)InfectionLatent infection
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