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Antigen Expression in Host Cells

Molecular classification: Protein/peptide, MHC Class I complex, MHC Class II complex

Overview

Antigen expression in host cells is a fundamental immunological process involving synthesis or uptake of proteins/peptides that become displayed at the cell surface bound to MHC molecules. This enables recognition by T lymphocytes and orchestrates downstream immune responses against infections, malignancies, or other challenges. The relationship between antigen abundance inside a cell and what is ultimately presented at its surface is complex—shaped both by cellular processing mechanisms and evolutionary pressures from pathogens adapting to evade detection within specific hosts.

Mechanism of action

Induction of antigen expression for immune priming

Biological functions

Immune surveillanceSelf/non-self discriminationAntigen presentationT cell activationInitiation of adaptive immunity

Disease associations

InfectionCancerAutoimmunity

Interacting drugs

Vaccines (DNA/mRNA)

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