Antigen presentation via major histocompatibility complex class I and class II (null)

Antigen presentation via major histocompatibility complex class I and class II on dendritic cells is a central process in adaptive immunity. MHC class I molecules present peptides derived from intracellular proteins (such as viral or tumor antigens) to CD8+ cytotoxic T cells, while MHC class II molecules present peptides from extracellular proteins to CD4+ helper T cells. Dendritic cells, as professional antigen-presenting cells, are uniquely capable of expressing both MHC class I and II molecules at high levels, and are critical for initiating T cell responses. The process relies on proteolytic generation of peptides and their loading onto MHC molecules, followed by transport to the cell surface for immune surveillance. The genes encoding these proteins are highly polymorphic, providing diversity in peptide binding and immune recognition[6][7][5][4][2][3].\n\nNote: This entry is not a single gene, protein, or canonical target and should be redefined if a specific MHC molecule (e.g., "HLA-A2" or "HLA-DRB1") or a dendritic cell receptor is the intended subject.

Other names

Antigen presentation via MHC-I and MHC-IIAntigen display on dendritic cells via MHCMHC-mediated antigen presentation

Enhancement or inhibition of antigen processing/presentation to modulate immune recognition of cells (e.g., upregulation of MHC-II for vaccines, proteasome inhibition to decrease MHC-I peptide loading); Blockade of downstream T cell activation (e.g., immune checkpoint inhibitors act downstream but depend on this process)