Target intelligence / Profile preview

Antigen presentation via major histocompatibility complex class I pathway (MHC class I pathway)

Target: MHC class I pathway
Molecular classification: Cellular process, Immune pathway

Overview

The antigen presentation via major histocompatibility complex class I pathway is central for immune surveillance against intracellular infections and malignancies. It involves proteasomal degradation of endogenous proteins into peptides that are loaded onto newly formed MHC-I complexes within the ER before being presented at the cell surface for recognition primarily by CD8+ cytotoxic T lymphocytes.

Biological functions

Antigen presentationImmune surveillanceT cell activationNK cell regulation

Disease associations

Antiviral immunityTumor immunityAutoimmunityInfectionCancer

Safety considerations

Immune evasion by viruses/tumorsAutoimmune diseases if tolerance mechanisms fail

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