Antigen Presentation via Transgene Expression (N/A)

Antigen presentation via transgene expression refers to the cellular process where antigens encoded by a transgene are processed and presented on MHC molecules, leading to T cell activation and immune responses. This process is critical in gene therapy, influencing therapeutic efficacy and potential immunogenicity. It involves antigen-presenting cells (APCs) processing transgenic proteins and presenting them on MHC class I or II molecules, stimulating CD8+ or CD4+ T cell responses. Modulation strategies include incorporating microRNA-binding sites in vector constructs and fusion with viral inhibitors to control off-target expression and inhibit CTL-mediated clearance, respectively. This phenomenon has clinical relevance in monitoring gene therapies but also poses challenges due to potential immune-mediated elimination of modified cells.

N/A