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Antigen-presenting cell activation via heat shock protein-mediated cross-presentation

Molecular classification: Immune process, Cellular process

Overview

Antigen-presenting cell (APC) activation via heat shock protein (HSP)-mediated cross-presentation of tumor antigens is a key immunological process in which HSPs, acting as molecular chaperones, bind tumor-derived peptides and facilitate their uptake and presentation by APCs—primarily dendritic cells (DCs) and macrophages. This mechanism enables the immune system to recognize and mount responses against tumor antigens that would otherwise evade detection.

Mechanism of action

HSP-mediated delivery of tumor antigens to APCs, leading to MHC I/II presentation and T cell activation.

Biological functions

Antigen presentationImmune responseT cell activationCross-presentation

Disease associations

CancerImmune evasion

Interacting drugs

Hyperthermia

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