Antigen-presenting cell surface receptors

"Antigen-presenting cell surface receptors" is a generic term for various receptors on the surface of professional antigen-presenting cells, including dendritic cells, macrophages, and B cells. Key examples include major histocompatibility complex (MHC) class I and II molecules, Fc gamma receptors, toll-like receptors, complement receptors, and co-stimulatory molecules such as CD80 (B7-1), CD86 (B7-2), and CD40. These receptors mediate the uptake and processing of antigens and subsequently present antigenic peptides on MHC molecules for recognition by T cells, thereby initiating and regulating adaptive immune responses. Each receptor type has specific functions in antigen recognition, internalization, processing, and T cell activation. The term as presented does not specify an individual molecular target but rather a family of molecules jointly critical for immune signaling and human disease pathophysiology[5][6][9].

Other names

Antigen-presenting cell (APC) receptorsAPC surface receptors