Antigen-specific T-cell receptor recognizing non-typeable Haemophilus influenzae-derived peptides presented on MHC class II (NTHi-specific TCR) (NTHi-specific TCR)

Antigen-specific T-cell receptors (TCRs) recognizing non-typeable Haemophilus influenzae (NTHi)-derived peptides presented on MHC class II molecules are essential for the adaptive immune response against this pathogen (Murphy et al., 2004, PubMed: 15175960). NTHi is a major cause of respiratory tract infections, including otitis media and exacerbations of chronic obstructive pulmonary disease (COPD) (Sethi & Murphy, 2008, PubMed: 18354102). These TCRs are expressed on CD4+ T cells and recognize specific peptide fragments from NTHi proteins like Protein D, P6, and OMP P2 when presented by MHC class II on antigen-presenting cells (Akkoyunlu et al., 1996, PubMed: 8913186; Murphy et al., 2003, PubMed: 12654743). Upon recognition, the TCR initiates signaling pathways that lead to T-cell proliferation and the secretion of cytokines such as IFN-gamma and IL-17 (King et al., 2003, PubMed: 12819088). This activation is crucial for orchestrating B-cell responses and enhancing the clearance of the bacteria from the respiratory mucosa. In therapeutic development, these TCRs are the focus of vaccine strategies aimed at inducing long-term memory and broad protection across diverse NTHi strains (Pichichero, 2013, PubMed: 23665144). Research into these receptors also helps in understanding how NTHi evades the immune system through antigenic variation and persistence in the host. Modulating the activity of these TCRs through vaccination or immunotherapy represents a promising approach to reducing the global burden of NTHi-associated diseases.

Other names

NTHi-specific T-cell receptorCD4+ T-cell receptor for NTHi antigensNon-typeable Haemophilus influenzae-specific TCRTCR recognizing NTHi peptides

Activation of CD4+ T helper cells through the recognition of NTHi-derived peptide epitopes presented by MHC class II molecules on antigen-presenting cells, facilitating cellular and humoral immunity.