Antioxidant 1 copper chaperone (ATOX1) mRNA (ATOX1 mRNA)

Antioxidant 1 copper chaperone (ATOX1) mRNA encodes a small cytosolic protein that plays a pivotal role in intracellular copper trafficking and homeostasis (UniProt O00170). The ATOX1 protein binds monovalent copper ions and delivers them to the copper-transporting ATPases, ATP7A and ATP7B, which are essential for copper secretion and the activation of copper-dependent enzymes (NCBI Gene 475). In various cancers, ATOX1 is overexpressed and promotes tumor progression, angiogenesis, and metastasis by supplying copper to enzymes such as lysyl oxidase (PubMed: 28415612). Targeting the ATOX1 mRNA using RNA interference (siRNA) or antisense oligonucleotides (ASOs) aims to deplete the protein reservoir, thereby disrupting the copper-dependent pathways that fuel malignancy (PubMed: 31110044). Beyond its chaperone function, ATOX1 also acts as an antioxidant and a copper-dependent transcription factor, further influencing cell proliferation and survival (PubMed: 18256283). Therapeutic challenges include the risk of systemic copper deficiency, which can lead to neurological impairment or connective tissue disorders. Consequently, monitoring ATOX1 expression levels is crucial for patient selection and assessing therapeutic efficacy.

Other names

HAH1 mRNAATX1 mRNACopper chaperone ATOX1 mRNAAntioxidant protein 1 mRNA

RNA interference or antisense-mediated degradation of mRNA to prevent translation of the ATOX1 protein.