Antioxidant enzyme pathway

"Antioxidant enzyme pathways" is not a single molecular target but rather refers to a group of endogenous enzymatic systems that protect cells from oxidative damage by neutralizing reactive oxygen species (ROS) and maintaining redox balance. The main classes of antioxidant enzymes include superoxide dismutase (SOD), catalase, glutathione peroxidase, glutathione reductase, and peroxiredoxins[3][6]. These enzymes work in concert to detoxify ROS such as superoxide anion (O2•−), hydrogen peroxide (H2O2), and lipid hydroperoxides. Each class has distinct mechanisms; for example, SOD converts superoxide into hydrogen peroxide, which is then broken down by catalase or glutathione peroxidase[3]. Peroxiredoxins also play a key role in reducing peroxides and regulating redox signaling[2]. These pathways are crucial for cellular defense against oxidative stress implicated in various diseases including cancer, neurodegeneration, cardiovascular disorders, and inflammation[6]. However, "Antioxidant enzyme pathways" does not refer to a specific protein or druggable target but rather an entire network/process involving multiple enzymes. Because this entry describes a broad biological process rather than an individual molecule or receptor typically considered as therapeutic targets (such as receptors or single enzymes), it should be flagged as incorrect for the purpose of structured drug-target information extraction. Individual components like "Superoxide dismutase," "Catalase," or "Glutathione peroxidase" would be appropriate canonical targets instead[3][6].

Other names

Antioxidant enzymesEnzymatic antioxidant pathwaysEndogenous antioxidant defense system