Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Antioxidant Pathways
- Molecular classification
- Biochemical Pathway, Enzyme Network, Redox System
01
Overview
Antioxidant pathways are a complex network of biochemical processes and molecular systems that protect cells from oxidative stress by neutralizing reactive oxygen species (ROS) and other free radicals. These pathways involve both enzymatic (e.g., superoxide dismutase, catalase, glutathione peroxidase) and non-enzymatic components (e.g., vitamins C and E, glutathione, polyphenols), working together to prevent cellular damage caused by oxidation and maintain redox homeostasis. Dysregulation of these pathways is implicated in a wide range of diseases, making them a potential therapeutic target.
- Other names
- Redox HomeostasisReactive Oxygen Species (ROS) DetoxificationOxidative Stress Defense
02
Mechanism of action
Varies depending on specific antioxidants; includes direct ROS scavenging, enzymatic conversion of ROS, regeneration of other antioxidants, metal ion chelation, and regulation of antioxidant gene expression.
03
Biological functions
Neutralization of Reactive Oxygen Species (ROS)Redox Homeostasis MaintenanceCellular Protection Against Oxidative StressRegulation of Gene ExpressionAutophagy ModulationRadical Scavenging
04
Disease associations
AgingCancerCardiovascular DiseasesNeurodegenerative DiseasesDiabetes ComplicationsInflammatory Disorders
05
Safety considerations
Potential for antioxidant supplementation to interfere with redox signalingPossible pro-oxidant effects at high dosesVariability in individual responses to antioxidant therapiesDrug interactions with antioxidant supplements
06
Interacting drugs
N-Acetylcysteine (NAC)
6 more in the full profile.
07
Biomarkers
Malondialdehyde (MDA)8-Hydroxydeoxyguanosine (8-OHdG)Glutathione Peroxidase (GPx) ActivitySuperoxide Dismutase (SOD) ActivityTotal Antioxidant Capacity (TAC)
Beyond the preview
Go deeper on Antioxidant Pathways.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Antioxidant Pathways.