Target intelligence / Profile preview

Antiplatelet action (Not applicable)

Target
Not applicable
Molecular classification
Enzymes, Receptors, Proteins
01

Overview

Antiplatelet drugs are a class of medications that prevent platelet aggregation and blood clot formation, primarily used to prevent cardiovascular events such as heart attacks and strokes. They target various molecules involved in platelet activation, including enzymes like cyclooxygenase and receptors like P2Y12 and Glycoprotein IIb/IIIa.

Other names
Antiplatelet drugsAntiaggregants
02

Mechanism of action

Inhibition of cyclooxygenase (COX-1) by aspirin, blockade of ADP receptors (P2Y12) by clopidogrel and prasugrel, inhibition of phosphodiesterase by dipyridamole, blockade of Glycoprotein IIb/IIIa receptors by abciximab and tirofiban

03

Biological functions

Signal transductionPlatelet aggregationBlood clotting
04

Disease associations

Cardiovascular diseaseStrokeMyocardial infarction
05

Safety considerations

Increased risk of bleedingGastrointestinal side effects with aspirinPotential for drug resistance or variability in response to drugs like clopidogrel
06

Interacting drugs

Aspirin

6 more in the full profile.

07

Biomarkers

Platelet function tests

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