Aortic valve (null)

The aortic valve is a trileaflet, semilunar valve located between the left ventricle of the heart and the ascending aorta. It is composed of three thin, flexible leaflets (cusps) made mostly of collagen surrounded by an endothelial lining, anchored by the aortic annulus and supported by a fibrous skeleton. The aortic valve ensures unidirectional blood flow during systole (ventricular contraction) and prevents retrograde flow of blood into the left ventricle during diastole. The valve operates under high pressure and is subject to age- and disease-related degenerative changes, as well as congenital malformations such as bicuspid aortic valve. Dysfunction of the native aortic valve is a major cause of cardiovascular morbidity and may necessitate surgical or interventional replacement with prosthetic or bioprosthetic valves[1][5][3]. Note: - "Native aortic valve" is not a molecular target recognized in drug development (such as a receptor, enzyme, or signaling protein). It is a gross anatomical structure with critical physiological and pathological roles, but not a target for drug binding or modulation at the molecular level[1][5][3]. - In clinical and research contexts, interventions on the aortic valve are primarily surgical or device-based, not pharmacological at the level of direct molecular modification.

Other names

Native aortic valvenative semilunar aortic valve

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