AP-1 complex subunit mu-1 (AP1M1)

AP-1 complex subunit mu-1 is a protein encoded by the AP1M1 gene that forms part of the clathrin-associated adaptor protein complex 1 (AP-1). This medium (mu) subunit associates with other adaptin proteins to form a heterotetrameric complex, which mediates the recruitment of clathrin to membranes in the trans-Golgi network and endosomes. AP-1 recognizes specific sorting signals on the cytosolic tails of cargo proteins, thus linking them to clathrin-coated vesicles and facilitating protein sorting and intracellular trafficking within the secretory and endocytic pathways[1][3][8]. The protein is essential for Golgi-to-endosome transport and is predicted to be crucial in processes like melanosome organization[1][4][8]. Its dysfunction is linked to human diseases involving protein trafficking defects, but no approved drugs directly target this subunit.

Other names

AP1M1CLAPM2AP47Mu1AClathrin Assembly Protein Complex 1 Mu-1 Medium Chain 1Adaptor Related Protein Complex 1 Mu 1 SubunitGolgi Adaptor HA1/AP1 Adaptin Mu-1 SubunitAdaptor Protein Complex AP-1 Subunit Mu-1Clathrin Coat-Associated Protein AP47Clathrin Coat Assembly Protein AP47AP-Mu Chain Family Member Mu1AMu-Adaptin 1Mu1A-AdaptinCLTNMClathrin Assembly Protein Complex 1 Medium Chain 1Clathrin Assembly Protein Complex 1, Medium ChainClathrin Assembly Protein Complex AP1, Mu SubunitAdaptor-Related Protein Complex 1, Mu 1 SubunitAdapter-Related Protein Complex 1 Subunit Mu-1Adaptor-Related Protein Complex 1 Subunit Mu-1Adaptor Protein Complex AP-1 Mu-1 SubunitGolgi Adaptor AP-1 47 KDa ProteinClathrin Adaptor Protein AP47HA1 47 KDa SubunitMU-1A[3]