AP-3 complex subunit mu-1 (AP3M1)

AP-3 complex subunit mu-1 is the medium (mu) subunit of the adaptor protein complex 3 (AP-3), a heterotetrameric complex composed of two large subunits, a medium subunit, and a small subunit. AP-3 is primarily associated with the Golgi region and peripheral intracellular structures, where it facilitates the formation of vesicles and sorting of proteins, especially into lysosomal and endosomal pathways. The AP-3 complex plays a crucial role in neural vesicle trafficking and cargo selection for synaptic and secretory vesicles, and mutations in AP-3 components have been linked to Hermansky-Pudlak syndrome, a genetic disorder affecting lysosome-related organelles[1][3][5][6]. AP3M1 is not a direct therapeutic target (such as a receptor, enzyme, or transporter) but may be of interest due to its role in vesicle trafficking and disease association; no known drugs directly interact with AP3M1, and it is not used as a biomarker or drug target in current therapeutic contexts[1][5]. It is best classified under "Other" for molecular classification, since it acts as an adaptor protein within an intracellular trafficking complex, rather than as a signaling, receptor, or enzyme protein[1][3][5].

Other names

Adaptor related protein complex 3 subunit mu 1AP-3 adaptor complex mu3A subunitMu-adaptin 3AMu3A-adaptinAP-3 adapter complex mu3A subunitAdapter-related protein complex 3 mu-1 subunitClathrin adaptor complex AP3, mu-3A subunit