APC membrane recruitment protein 2 (AMER2)

APC membrane recruitment protein 2 (AMER2) is a membrane-associated adaptor protein that plays a dual role in regulating both Wnt signaling and microtubule stability. At the plasma membrane, AMER2 binds to phosphatidylinositol 4,5-bisphosphate via lysine-rich motifs, which enables recruitment of the APC tumor suppressor. This assembly supports the formation of the β-catenin destruction complex, thus acting as a negative regulator of the canonical Wnt/β-catenin signaling pathway. AMER2 also interacts with microtubule plus-end tracking proteins like EB1, affecting microtubule stability and cell migration. Through these functions, AMER2 influences cellular motility and neuroectodermal patterning; mutations in related gene families have been implicated in certain bone disorders and may play a role in tumor suppression. No evidence indicates it is a current therapeutic target, nor are there known drugs or mechanisms of action involving it at this time. No relevant biomarkers or safety concerns are reported in the literature reviewed.

Other names

FAM123AAmer2FLJ25477Protein FAM123Afamily with sequence similarity 123A