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Target intelligence / Profile preview
APC membrane recruitment protein 3 (AMER3)
- Target
- AMER3
- Molecular classification
- Other (No evidence of it being a receptor, enzyme, transporter, ion channel or transcription factor; part of the Amer protein family with membrane-associated functions)
01
Overview
APC membrane recruitment protein 3 (AMER3) is a membrane-associated protein that regulates the canonical Wnt signaling pathway by binding phosphatidylinositol 4,5-bisphosphate and beta-catenin, translocating to the cell membrane. Unlike its paralogs Amer1 and Amer2 (which inhibit Wnt signaling), AMER3 acts as an activator, indicating a distinctive, non-redundant cellular function. Diseases associated with AMER3 include isolated tracheo-esophageal fistula and tracheoesophageal fistula with or without esophageal atresia. There is presently no evidence for its role as a therapeutic target, nor are there known interacting drugs or established biomarker functions
- Other names
- FAM123CAmer3FLJ38377Protein FAM123CFamily with sequence similarity 123CAMER3
02
Mechanism of action
None reported (no drugs are shown to act directly via AMER3)
03
Biological functions
Regulation of canonical Wnt signaling pathway (AMER3 acts as a positive regulator, in contrast to Amer1 and Amer2, which are inhibitors)Beta-catenin bindingPhosphatidylinositol-4,5-bisphosphate binding (membrane association)Regulation of cell membrane localization and signaling
04
Disease associations
Associated with Isolated tracheo-esophageal fistulaAssociated with tracheoesophageal fistula with or without esophageal atresiaNo evidence for direct involvement in cancer, inflammation, neurodegenerative or cardiovascular diseases presented in current sources.
05
Safety considerations
None reported in the context of drug development or clinical use
06
Interacting drugs
None reported in current literature or drug target databases
07
Biomarkers
None known for patient selection or efficacy monitoring
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