Target intelligence / Profile preview

Apical Membrane Antigen 1 (AMA1)

Target: AMA1
Molecular classification: Membrane protein, Antigen

Overview

Apical membrane antigen 1 (AMA1) is a key protein expressed by the invasive merozoite form of Plasmodium species, most notably *Plasmodium falciparum*. AMA1 plays a central and essential role in the invasion of host erythrocytes (red blood cells), making it a critical factor for parasite survival during the blood stage of infection. It interacts with RON2 to form the moving junction during invasion.

Mechanism of action

Inhibition of AMA1-RON2 interaction disrupts moving junction formation, blocking erythrocyte invasion.

Biological functions

Erythrocyte invasionHost cell entryMoving junction formation

Disease associations

InfectionMalaria

Safety considerations

High sequence polymorphism limits cross-strain immunity.Development of broadly protective vaccines is challenging.

Beyond the preview

Go deeper on Apical Membrane Antigen 1 (AMA1).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Apical Membrane Antigen 1 (AMA1).

Explore the full profile