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Target intelligence / Profile preview
Apolipoprotein A-I (ApoA-I)
- Target
- ApoA-I
- Molecular classification
- Apolipoprotein, Lipid binding protein
01
Overview
Apolipoprotein A-I (ApoA-I) is the major structural and functional protein component of high-density lipoprotein (HDL), playing a central role in reverse cholesterol transport, cardiovascular protection, and immune modulation. It facilitates cholesterol efflux from peripheral tissues and acts as a cofactor for LCAT. Defects in APOA1 are linked to Tangier disease and amyloidosis, while low levels are associated with increased cardiovascular risk. It can also bind endotoxins and influence inflammation.
- Other names
- Apolipoprotein AIApo AI
02
Mechanism of action
N/A
03
Biological functions
Reverse cholesterol transportLipid metabolismLCAT cofactorAnti-inflammatoryEndotoxin binding
04
Disease associations
Cardiovascular diseaseTangier diseaseAmyloidosisSepsis
05
Biomarkers
Cardiovascular risk assessment (apoB/apoA-I ratio)
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