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Target intelligence / Profile preview
Apolipoprotein B (ApoB)
- Target
- ApoB
- Molecular classification
- Apolipoprotein, Structural protein
01
Overview
Apolipoprotein B is an essential structural component required for assembly/secretion/functionality of all major atherogenic plasma lipoproteins except HDL. Its measurement offers direct insight into cardiovascular risk beyond traditional cholesterol metrics due to its one-to-one correspondence with potentially pathogenic particle numbers.
- Other names
- ApoB-100ApoB-48
02
Mechanism of action
Drugs targeting ApoB aim to reduce its levels or inhibit its function in assembling and transporting atherogenic lipoproteins, thereby reducing the risk of cardiovascular disease.
03
Biological functions
Lipid transportCholesterol transportLDL receptor bindingVLDL assemblyChylomicron assembly
04
Disease associations
AtherosclerosisCardiovascular diseaseHyperlipidemiaFamilial hypobetalipoproteinemiaAbetalipoproteinemiaCoronary artery disease
05
Safety considerations
Potential for liver toxicity with drugs affecting lipid metabolismDrug interactions affecting lipid levelsRisk of fat malabsorption with significant ApoB reduction
06
Biomarkers
Plasma ApoB concentrationLDL-cholesterolTotal cholesterolVLDL levelsIDL levels
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