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Target intelligence / Profile preview
Apolipoprotein B100 (ApoB100)
- Target
- ApoB100
- Molecular classification
- Lipoprotein, Structural protein
01
Overview
Apolipoprotein B100 (apoB100) is a large glycoprotein essential for lipid and cholesterol metabolism. It is the primary structural and functional protein component of LDL, facilitating LDL receptor-mediated endocytosis and playing a key role in the development of atherosclerosis. Measurement of apoB levels is used to assess cardiovascular risk and diagnose hypercholesterolemia. It is a therapeutic target for lipid-lowering medications.
- Other names
- ApoBApo-B 100
02
Mechanism of action
Statins: HMG-CoA reductase inhibitors, reduce cholesterol synthesis. Ezetimibe: Inhibits intestinal cholesterol absorption. PCSK9 inhibitors: Increase LDL receptor availability. Mipomersen: Antisense oligonucleotide, inhibits apoB100 synthesis. Lomitapide: Inhibits microsomal triglyceride transfer protein (MTTP), reduces VLDL secretion.
03
Biological functions
Lipid transportCholesterol transportLDL receptor bindingVLDL assembly
04
Disease associations
Cardiovascular diseaseAtherosclerosisHypercholesterolemiaCoronary artery disease
05
Safety considerations
Liver toxicity (statins, lomitapide)Myopathy (statins)Injection site reactions (mipomersen)Gastrointestinal side effects (ezetimibe, lomitapide)
06
Interacting drugs
Statins
4 more in the full profile.
07
Biomarkers
ApoB100 levelsLDL cholesterol levelsNon-HDL cholesterolTriglycerides
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