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Target intelligence / Profile preview
Apolipoprotein C-II (ApoC-II)
- Target
- ApoC-II
- Molecular classification
- Apolipoprotein
01
Overview
Apolipoprotein C-II is an essential regulator of lipid metabolism through its role as an activator of endothelial-bound lipoprotein lipase. Its proper concentration is critical—both deficiencies due to genetic mutations in APOC2 and excessive circulating levels disrupt normal lipid processing leading to significant metabolic disorders characterized by elevated blood fats. Genetic testing distinguishes between primary defects in apo-CII versus other causes like LPL deficiency. Therapeutically modulating apo-CII remains an area under active research given its central role in controlling plasma triglyceride levels.
- Other names
- Apolipoprotein C2
02
Mechanism of action
Modulation of ApoC-II levels to influence LPL activity and triglyceride metabolism
03
Biological functions
Lipoprotein lipase (LPL) cofactorTriglyceride hydrolysisLipid metabolism
04
Disease associations
HypertriglyceridemiaHyperlipoproteinemia type IBPancreatitis
05
Safety considerations
Excessive reduction of ApoC-II leading to impaired LPL activityPancreatitis due to severe hypertriglyceridemia
06
Interacting drugs
Statins
4 more in the full profile.
07
Biomarkers
Plasma triglyceridesCholesterolChylomicronsApoC-II levels
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