Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Apolipoprotein C3 (ApoC3)
- Target
- ApoC3
- Molecular classification
- Apolipoprotein
01
Overview
Apolipoprotein C3 (ApoC3) is a small apolipoprotein primarily produced by the liver and small intestine. It inhibits lipoprotein lipase (LPL) and hepatic lipase, thereby delaying the clearance of triglyceride-rich particles from the bloodstream. Elevated ApoC3 levels are associated with hypertriglyceridemia and increased cardiovascular risk. It promotes assembly and secretion of VLDL particles from hepatocytes under lipid-rich conditions, with recent evidence suggesting an intracellular function for ApoC3.
- Other names
- apo-CIII
02
Mechanism of action
Inhibition of lipoprotein lipase (LPL) and hepatic lipase, interference with triglyceride-rich lipoprotein clearance, modulation of VLDL assembly and secretion.
03
Biological functions
Lipid metabolism regulationInhibition of lipoprotein lipase (LPL)Inhibition of hepatic lipaseRegulation of triglyceride-rich lipoprotein clearanceVLDL assembly and secretion
04
Disease associations
HypertriglyceridemiaCardiovascular diseaseAtherosclerosisCoronary heart diseaseType 2 diabetes mellitusNon-alcoholic fatty liver disease
05
Safety considerations
Elevated ApoC3 levels associated with increased cardiovascular riskGenetic variants leading to increased expression may predispose individuals to non-alcoholic fatty liver disease
06
Biomarkers
Plasma ApoC3 levelsAPOC3 gene haplotypes
Beyond the preview
Go deeper on Apolipoprotein C3 (ApoC3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Apolipoprotein C3 (ApoC3).