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Target intelligence / Profile preview
Apolipoprotein E2 (ApoE2)
- Target
- ApoE2
- Molecular classification
- Apolipoprotein, Lipoprotein component
01
Overview
Apolipoprotein E2 (ApoE2) is one of three major isoforms of apolipoprotein E, a protein involved in lipid metabolism and transport. ApoE2 exhibits reduced binding affinity for the LDL receptor compared to other isoforms, affecting lipoprotein clearance and influencing the risk of Alzheimer's disease and type III hyperlipoproteinemia.
- Other names
- Apolipoprotein E isoform Epsilon 2APOE2Apo-E2
02
Mechanism of action
Modulates lipid transport and clearance by binding to lipoprotein receptors and heparan sulfate proteoglycans.
03
Biological functions
Lipid transportLipid metabolismCholesterol transportTriglyceride transportAmyloid-beta clearanceReelin signalingMicroglial function
04
Disease associations
Alzheimer's diseaseType III hyperlipoproteinemiaCardiovascular diseaseTauopathiesCerebrovascular disordersCerebral amyloid angiopathy
05
Safety considerations
Increased risk of type III hyperlipoproteinemia in APOE2 homozygotesPotential increased susceptibility to certain tauopathies or cerebrovascular disorders despite neuroprotective effects against Alzheimer's
06
Biomarkers
APOE2 genotypePlasma lipid levelsAmyloid plaque loadTau pathology
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