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Target intelligence / Profile preview
Apolipoprotein E4 (APOE4)
- Target
- APOE4
- Molecular classification
- Apolipoprotein, Lipid Transport Protein
01
Overview
Apolipoprotein E4 is a critical fat-binding protein involved in systemic and cerebral lipid homeostasis whose structural properties distinguish it from other isoforms. Its presence significantly increases susceptibility to late-onset Alzheimer’s disease through complex effects on cellular lipid handling and neuronal health while also impacting cardiovascular risk profiles due to its fundamental metabolic roles.
- Other names
- ApoE4APOE ε4Apolipoprotein E isoform 4
02
Mechanism of action
Modulation of lipid metabolism and amyloid plaque dynamics.
03
Biological functions
Lipid transportCholesterol transportReceptor-mediated endocytosisLipid metabolismCholesterol metabolism
04
Disease associations
Alzheimer's diseaseCardiovascular diseaseNeurodegenerative disease
05
Safety considerations
Increased risk of late-onset Alzheimer's diseaseIncreased risk of cardiovascular disease
06
Biomarkers
APOE4 genotype (risk stratification for Alzheimer's disease)Lipid levels
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