Apolipoprotein L domain-containing protein 1 (APOLD1)

Apolipoprotein L domain-containing protein 1 (APOLD1) is an endothelial cell early response protein, highly expressed in blood vessels where it regulates endothelial signaling, vascular homeostasis, and barrier function[1][2][3][5]. Loss of APOLD1 in animal models leads to increased risk of thrombosis, highlighting a protective cardiovascular role[1]. APOLD1 is also regulated by neurotrophic factors and is induced by metabolic or physical stress, suggesting roles beyond the vasculature, particularly in neural function and inflammation[1]. Changes in APOLD1 expression have been linked to cancer, diabetic nephropathy, and neuroinflammatory processes such as those observed in schizophrenia, and it is emerging as both a functional effector in vascular biology and a potential biomarker for pathological tissue remodeling[1][3]. No therapeutic drugs are known to directly target APOLD1, and it is not classified as a classical receptor, enzyme, or drug target at this time[3][5].

Other names

VERGEFLJ25138DKFZP434F0318vascular early response gene proteinBDVASapolipoprotein L domain containing 1APOLD1