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Target intelligence / Profile preview
Apoptosis Inducing Factor 1 (AIFM1)
- Target
- AIFM1
- Molecular classification
- Oxidoreductase, Flavoprotein, Other
01
Overview
Apoptosis Inducing Factor 1 (AIFM1) is a flavoprotein located in the mitochondrial intermembrane space. It plays a dual role in cellular physiology: it is essential for mitochondrial respiratory function under normal conditions and acts as a key effector of caspase-independent programmed cell death (apoptosis) when cells are exposed to apoptotic stimuli.
- Other names
- PDCD8Programmed cell death protein 8Apoptosis-inducing factor, mitochondrion-associated, 1
02
Mechanism of action
AIFM1, upon apoptotic insult, translocates to the nucleus where it induces chromatin condensation and large-scale DNA fragmentation independently of caspases.
03
Biological functions
Redox regulationApoptosisMitochondrial respiratory functionDNA degradation
04
Disease associations
Neurodegenerative diseaseMuscle atrophyIschemic injuryOther
05
Safety considerations
Mutations or deficiencies in AIFM1 lead to severe mitochondrial dysfunctions.
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