Apoptosis-inducing pathway

Apoptosis-inducing pathways" refers to the network of molecular signals that activate programmed cell death in response to various internal and external cues. These pathways are broadly divided into the intrinsic (mitochondrial) and extrinsic (death receptor-mediated) mechanisms. The intrinsic pathway is controlled by the balance of pro- and anti-apoptotic Bcl-2 family proteins and mitochondrial events, while the extrinsic pathway involves ligand-induced activation of cell surface death receptors leading to caspase activation. Both routes converge at the execution phase, marked by activation of executioner caspases that orchestrate cell destruction. Dysregulation of apoptosis-inducing pathways is central to the pathogenesis of various diseases, especially cancer, making individual pathway components key drug targets for therapeutic intervention[1][2][3][4][5][6].

Other names

Apoptotic signaling pathwayprogrammed cell death pathwaycell death pathway