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Target intelligence / Profile preview
Apoptosis Induction via Non-Retinoid Mechanisms (Non-Retinoid Apoptosis)
- Target
- Non-Retinoid Apoptosis
- Molecular classification
- Signaling pathway, Apoptosis pathway, Mitochondrial pathway, Death receptor pathway, Cytotoxic pathway
01
Overview
Non-retinoid mechanisms of apoptosis induction encompass various cellular pathways that trigger programmed cell death independent of retinoids. These pathways, including the intrinsic (mitochondrial), extrinsic (death receptor), and perforin/granzyme pathways, are crucial for maintaining tissue homeostasis, eliminating damaged cells, and regulating immune responses. Dysregulation of these pathways is implicated in various diseases, including cancer, autoimmune disorders, and neurodegeneration.
- Other names
- Non-retinoid programmed cell deathRetinoid-independent apoptosisIntrinsic apoptosis pathwayExtrinsic apoptosis pathwayPerforin/Granzyme mediated apoptosis
02
Mechanism of action
Various, depending on the specific pathway. Includes mitochondrial outer membrane permeabilization, death receptor activation, and granzyme-mediated caspase activation.
03
Biological functions
ApoptosisCell deathImmune responseTissue homeostasisTumor suppression
04
Disease associations
CancerAutoimmune disordersNeurodegenerative diseasesInfectious diseases
05
Safety considerations
Off-target apoptosis in healthy cellsInduction of inflammationDevelopment of resistance mechanisms
06
Interacting drugs
Chemotherapeutic agents (e.g., Cisplatin, Doxorubicin)
3 more in the full profile.
07
Biomarkers
Cytochrome c releaseCaspase activation (e.g., caspase-3, caspase-8, caspase-9)Bcl-2 family protein expression (e.g., Bax/Bcl-2 ratio)Death receptor expression (e.g., Fas/CD95, TRAILR1/DR4, TRAILR2/DR5)Granzyme B levels
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