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Target intelligence / Profile preview
Apoptosis Inhibitor 5 (API5)
- Target
- API5
- Molecular classification
- Nuclear protein, Transcription factor, Other
01
Overview
API5, also known as Apoptosis Inhibitor 5, AAC-11, or FIF, is a nuclear protein with anti-apoptotic properties. It inhibits programmed cell death, particularly under conditions of growth factor deprivation. It plays a role in immune escape in tumors and participates in mRNA nuclear export. API5 interacts with several proteins involved in apoptosis, cell survival, immune response, transcription regulation, RNA export, and chromatin remodeling. Its heptad leucine repeat region is a potential therapeutic target.
- Other names
- AAC11FIFApoptosis Inhibitor AAC-11Fibroblast growth factor-2 interacting factor
02
Mechanism of action
Suppression of E2F1-induced apoptosis; Negative regulation of ACIN1-mediated DNA fragmentation; Modulation of ERα signaling pathway
03
Biological functions
Apoptosis inhibitionCell survivalmRNA nuclear exportImmune response modulationProtein-protein interaction
04
Disease associations
CancerAsbestos-related lung carcinomaLung cancerColon adenocarcinomaCervical cancer
05
Safety considerations
Overexpression in cancer cells may confer resistance to chemotherapy.
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