Apoptosis inhibitor 5 pseudogene 1 (API5P1)

Apoptosis inhibitor 5 pseudogene 1 (API5P1) is classified as a pseudogene in the human genome, meaning that it is homologous to a functional gene (in this case, API5) but does not encode a functional protein itself[7][1][5]. Pseudogenes can arise through gene duplication or retrotransposition events and typically lack biological activity. API5P1 is listed as a pseudogene by several authoritative resources, including the HUGO Gene Nomenclature Committee (HGNC), and has the locus type "pseudogene"[7]. There is no evidence that API5P1 plays a direct role in disease, is druggable, or acts as a receptor, enzyme, transcription factor, or other conventional molecular target in therapeutic contexts. Important Distinction: Confusion may arise because the functional gene API5 (Apoptosis inhibitor 5) is a protein-coding gene involved in apoptosis inhibition and associated with certain cancers[8][2][3]. However, API5P1 refers specifically to the non-functional pseudogene copy, and not to the active therapeutic target API5. For drug discovery or mechanistic biology interests, refer to "Apoptosis inhibitor 5" (API5), not API5P1.

Other names

API5L1Apoptosis inhibitor 5 pseudogene 1