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Apoptosis Inhibitor 5 Signaling Complex (None)
- Target
- None
- Molecular classification
- Protein complex, Scaffold protein
01
Overview
The Apoptosis Inhibitor 5 (API5/AAC-11) signaling complex is a multiprotein complex centered around the antiapoptotic protein API5. API5 functions as a scaffold to interact with several apoptosis-related proteins, most notably Acinus. This complex regulates apoptotic pathways, promoting cell survival particularly under stress conditions. Overexpression of API5 is associated with cancer and drug resistance, making the AAC-11 signaling complex a potential therapeutic target.
- Other names
- AAC-11 signaling complex
02
Mechanism of action
Disruption of AAC-11/API5 protein-protein interactions
03
Biological functions
Apoptosis regulationCell survivalProtein-protein interactionSignal transduction
04
Disease associations
CancerDrug resistance
05
Safety considerations
Potential for off-target effectsNeed for selective targeting of cancer cells
06
Biomarkers
AAC-11/API5 expression levels (prognostic in some cancers)
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