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Target intelligence / Profile preview
Apoptosis pathway in HPV-infected cells
- Molecular classification
- Signaling pathway, Apoptotic pathway, Viral oncoprotein interaction network
01
Overview
The apoptosis pathway in HPV-infected cells refers to the network of molecular mechanisms by which programmed cell death (apoptosis) is regulated or subverted during infection with human papillomavirus (HPV). High-risk HPVs inhibit both intrinsic and extrinsic apoptotic pathways, allowing infected cells to survive, proliferate, and potentially undergo malignant transformation. Key viral proteins involved include E5, E6, and E7, which target host proteins like p53, Bak/Bax, FADD, and caspases.
- Other names
- HPV-associated apoptosis pathwayApoptosis dysregulation in HPV infectionEvasion of apoptosis in HPV-infected cells
02
Mechanism of action
Targeting viral oncoproteins (E6/E7) to restore apoptotic sensitivity; restoring pro-apoptotic signals
03
Biological functions
Apoptosis inhibitionCell survivalImmune evasionCell proliferationViral replication
04
Disease associations
Cervical cancerHead and neck cancerAnogenital wartsHPV infectionCancer
05
Safety considerations
Off-target effects of viral oncoprotein inhibitorsImmune-related adverse eventsDevelopment of resistance
06
Biomarkers
p53 expressionBak/Bax levelsCaspase activityE6/E7 expression levelsHPV viral load
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