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Target intelligence / Profile preview
Apoptosis regulator BAK (BAK)
- Target
- BAK
- Molecular classification
- BCL-2 family protein, Pro-apoptotic protein
01
Overview
Apoptosis regulator BAK (BCL2 antagonist/killer 1, gene symbol: BAK1) is a pro-apoptotic member of the BCL-2 protein family. It plays a central role in the intrinsic (mitochondrial) pathway of apoptosis by promoting mitochondrial outer membrane permeabilization (MOMP), which is a critical step leading to programmed cell death. Defective regulation or expression levels of BAK are implicated in various cancers, while excessive activity may contribute to degenerative diseases.
- Other names
- BCL2 antagonist/killer 1BAK1
02
Mechanism of action
Promotes mitochondrial outer membrane permeabilization and cytochrome c release, triggering caspase activation and cell death.
03
Biological functions
ApoptosisMitochondrial outer membrane permeabilization (MOMP)Cell death
04
Disease associations
CancerNeurodegenerative disease
05
Safety considerations
Excessive BAK activity may contribute to degenerative diseases due to inappropriate cell loss.
06
Interacting drugs
WEHI-3773
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