Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Apoptosis regulator BCL-W (BCL-w)
- Target
- BCL-w
- Molecular classification
- Anti-apoptotic protein, Bcl-2 protein family member
01
Overview
BCL-w (BCL2L2) is an anti-apoptotic member of the BCL-2 family, promoting cell survival by inhibiting apoptosis. Its unique C-terminal helix regulates access to its BH3-binding groove, modulating interactions with pro-apoptotic proteins. Overexpression of BCL-w is implicated in cancer development and resistance to therapy, making it a potential therapeutic target and biomarker.
- Other names
- BCL2L2bcl-w
02
Mechanism of action
Sequestering pro-apoptotic BH3-only proteins; modulation of hydrophobic groove accessibility
03
Biological functions
Inhibition of apoptosisRegulation of cell motilityRegulation of senescenceCell survival
04
Disease associations
CancerDrug resistance
05
Safety considerations
Potential for off-target effects due to structural similarity with other Bcl-2 family membersDeveloping resistance to BCL-w inhibitors
06
Biomarkers
Prognostic marker in Burkitt lymphomaPrognostic marker in diffuse large B-cell lymphoma
Beyond the preview
Go deeper on Apoptosis regulator BCL-W (BCL-w).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Apoptosis regulator BCL-W (BCL-w).