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Target intelligence / Profile preview
Apoptosis regulator Bcl-xL (BCL-xL)
- Target
- BCL-xL
- Molecular classification
- Bcl-2 family protein
01
Overview
Bcl-xL is a key anti-apoptotic protein that regulates programmed cell death (apoptosis). It inhibits mitochondrial outer membrane permeabilization, preventing the release of pro-apoptotic factors and subsequent caspase activation. Overexpression of BCL-xL contributes to cancer cell survival and resistance to chemotherapy, making it a therapeutic target. Strategies include PROTACs and small molecules disrupting its interactions.
- Other names
- Bcl2-like 1 proteinBCL2L1
02
Mechanism of action
Inhibition of pro-apoptotic protein interactions, prevention of mitochondrial outer membrane permeabilization and cytochrome c release, inhibition of caspase activation
03
Biological functions
Anti-apoptosisRegulation of apoptosisInhibition of mitochondrial outer membrane permeabilization
04
Disease associations
CancerChemoresistance
05
Safety considerations
Thrombocytopenia (potential side effect of BCL-xL inhibition due to expression in platelets)On-target toxicity in normal tissues
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