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Target intelligence / Profile preview
Apoptosis Signal-Regulating Kinase 1 (ASK1)
- Target
- ASK1
- Molecular classification
- Enzyme, Serine/threonine protein kinase, MAP kinase family
01
Overview
Apoptosis Signal-Regulating Kinase 1 (ASK1), also known as MAP3K5, is a key component of the mitogen-activated protein kinase (MAPK) signaling pathway. It acts as an upstream activator of c-Jun N-terminal kinases (JNKs) and p38 MAPKs in response to various cellular stresses, including oxidative stress, endoplasmic reticulum stress, and calcium influx. Through these pathways, ASK1 regulates apoptosis, inflammation, and other stress responses. ASK1 activity is tightly regulated by multiple mechanisms involving proteins such as thioredoxin (Trx) and calcium/integrin-binding protein 1 (CIB1).
- Other names
- MAP3K5Mitogen-activated protein kinase kinase kinase 5
02
Mechanism of action
Small-molecule kinase inhibitor (for investigational inhibitors)
03
Biological functions
ApoptosisInflammationStress responseSignal transductionMetabolism regulation
04
Disease associations
CancerDiabetes mellitusRheumatoid arthritisCardiovascular diseasesNeurodegenerative disordersNon-alcoholic steatohepatitis (NASH)
05
Safety considerations
Dysregulated or hyperactive ASK1 signaling contributes to several diseases. May play protective roles depending on disease context.No approved clinical therapies directly target ASK1 yet.
06
Interacting drugs
K811
1 more in the full profile.
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