Apoptosis-stimulating of p53 protein 1 (PPP1R13B)

Apoptosis-stimulating of p53 protein 1 (PPP1R13B, also known as ASPP1) is a regulatory protein that enhances the pro-apoptotic functions of p53-family proteins by promoting their DNA binding and transcriptional activation at the promoters of proapoptotic genes[1][2][3][5][8][9]. It contains ankyrin repeats and an SH3 domain involved in protein-protein interactions and acts as a molecular scaffold. ASPP1 is mainly expressed in the cytosol and nucleoplasm and plays a key role in the intrinsic apoptotic pathway mediated by p53. It is implicated in cancer progression, where its downregulation is linked to epithelial-mesenchymal transition, increased invasion, and metastasis, particularly via modulation of the NF-κB/Snail2 pathway[4][6]. PPP1R13B has also been associated with rare syndromes such as Noonan syndrome 3 and 7[2]. No drugs are presently known to interact directly with PPP1R13B, but its biomarker potential and regulatory function in apoptosis make it of interest in oncology and cell death research.

Other names

Protein phosphatase 1 regulatory subunit 13BASPP1KIAA0771p53BP2-likep85Apoptosis-stimulating protein of p53, 1

Modulation of apoptosis through p53 activation; Inhibition of invasion/metastasis by maintaining epithelial phenotype; Regulation of transcriptional programs associated with cell death