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Target intelligence / Profile preview
Apoptotic Cell Membrane (N/A)
- Target
- N/A
- Molecular classification
- Cell Membrane, Lipid Bilayer
01
Overview
The apoptotic cell membrane refers to the plasma membrane of a cell undergoing apoptosis. It undergoes distinct biochemical and structural changes, including phosphatidylserine (PS) exposure, membrane blebbing, and fragmentation into apoptotic bodies. These changes serve as signals for recognition and clearance by phagocytes, ensuring non-inflammatory removal of dying cells.
- Other names
- Plasma membrane of apoptotic cellsMembrane of dying cellsBlebbing membraneApoptotic body membrane
02
Mechanism of action
N/A
03
Biological functions
Signaling for efferocytosisPrevention of inflammationFormation of apoptotic bodiesExternalization of phosphatidylserine
04
Disease associations
Cancer (clearance of tumor cells)Autoimmune disease (failure of apoptotic clearance)Neurodegenerative disease (inefficient removal of apoptotic neurons)Infectious disease (clearance of infected cells)
05
Safety considerations
Inefficient clearance can lead to inflammation and autoimmunitySecondary necrosis can release intracellular contents and trigger inflammationDAMP release if not properly cleared
06
Biomarkers
Phosphatidylserine (PS) exposureAnnexin V bindingMembrane blebbingApoptotic bodies
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