Apoptotic chromatin condensation inducer 1 (ACIN1)

Apoptotic chromatin condensation inducer 1 (ACIN1) encodes the nuclear protein Acinus, a multifunctional factor initially discovered for its involvement in apoptosis, primarily inducing chromatin condensation after activation by caspase-3, without direct DNA fragmentation[1][3][5]. Acinus is also an essential regulator of alternative splicing, acting within spliceosome-associated multiprotein complexes such as the exon junction complex (EJC) and the ASAP complex, which integrate cell death signals with gene expression programs[1][2][3]. Loss of ACIN1 is embryonic lethal, underscoring its developmental importance; tissue-specific knockout studies demonstrate effects on muscle regeneration and splicing of muscle-related genes[2]. Post-translational modifications (phosphorylation by Akt and SRPK2) influence its stability and apoptotic function, especially in cancer cell contexts[1]. While ACIN1 plays dual roles in cell death and RNA processing, there is currently no evidence that it is a direct therapeutic target or clinical biomarker[1][2][3][5].

Other names

AcinusApoptotic chromatin condensation inducer in the nucleusKIAA0670fSAP152 (functional spliceosome-associated protein 152)ACINUSACNApoptotic chromatin condensation inducer 1

Not applicable. Drugs do not directly target ACIN1.